research
Posted Apr 21Associate Scientist, R&D
at Natera
Austin, United StatesHybrid
Responsibilities
- Design, develop, and validate automated high-throughput NGS assays that will be run in a commercial CLIA laboratory
- Independently design and execute moderate to high complexity experiments
- Collaborate with assay development scientists on the specifications of assay, reagent, equipment and quality metrics for existing and future production assays
- Coordinate across multiple internal groups (automation engineering, laboratory operations, bioinformatics, statistics, project and product management) and serve as point person to ensure the successful identification and timely execution of projects
- Write documentation and SOPs, and train lab operations operators on protocols
- Oversee validation activities
- Identify areas for continuous improvement and actively contribute to the effort of introducing better practices to improve production workflows and shorten TAT for patient samples
- Demonstrated track record of development and validation of automated protocols for CLIA
Requirements
- The ideal candidate is a driven professional who maintains broad knowledge of state-of-the-art principles and theories with an in-depth understanding of applicability to oncology research.
- experience in both assay development and high throughput automation that can work effectively in a fast-paced environment to ensure that the highest quality clinical assays are developed and launched for our patients. PRIMARY RESPONSIBILITIES:
- BA/BS with 6 years experience or MS with 3 years
- experience in assay development and automation for the genomics
- Strong understanding of the chemistry underlying nucleic acid extraction, PCR, NGS library preparation, and hybrid capture technologies Hands-on
- experience in reagent preparation and quality control for NGS-based assays •
- Data analysis (JMP) required, coding skills (Python or R) are a plus
- Experience designing and executing studies including stability, guard banding, reproducibility and repeatability, and validation •
- Experience working in a regulated laboratory environment under CLIA/CAP, NYSDOH, IVD is a plus
- Ability to collaborate cross-functionally with other groups (CLIA, lab operations QA, Automation, Research)