research
Posted May 12Principal Scientist - Antibody Characterization, Optimization & Immunology
at ezyVet
Westbrook, United StatesOn-site
Responsibilities
- Lead biophysical characterization (BLI, SPR), developability assessments, epitope mapping, evaluate binding kinetics, stability, and sequence liabilities — executing optimization campaigns via site-directed mutagenesis and structure-guided engineering.
Requirements
- Join IDEXX's Molecular Analytics and Bioanalytical Research and Instrumentation Center (BRIC) at the intersection of immunology and antibody science — where deep knowledge of the immune system directly drives the development of diagnostic products used by veterinarians worldwide.
- As a Principal Scientist , you will apply expertise spanning adaptive immunity, antibody biology, and biophysical characterization across a portfolio unmatched in the industry, working with cross-functional teams to advance candidates from immunological concepts to characterized lead.
- What Will You Do Leverage automated single-cell biology platforms and deep understanding of B cell activation, affinity maturation for high-throughput screening, and selection of high-quality antibody candidates against novel targets.
- Apply humoral immunology knowledge — antibody isotypes, Fc effector biology, T cell help, and antigen presentation — to guide candidate generation, selection, and optimization decisions.
- What Do You Need to Succeed Ph.D. in Immunology, Biochemistry, Molecular Biology, Biophysics, or related field with 5–7 years of industry/academia
- experience Deep understanding of adaptive immunity: B and T cell biology, humoral immune responses, and antibody affinity maturation Proven
- experience in antibody development — biophysical characterization, and lead optimization Hands-on expertise in biophysical methods and molecular biology skills including cloning and mammalian expression systems Multi-species antibody
- If meaningful work and a sense of purpose are at the top of your list, you’ll find it here.
Benefits
- Experience with automated single-cell biology platforms for high-throughput antibody screening and functional cell profiling Strong planning, execution, decision-making, and problem-solving skills with a demonstrated ability to drive complex projects to completion Excellent written and verbal communication; demonstrated ability to lead and influence cross-functional teams What you can expect from us: Salary range starting at $120,000 based on