engineering
Posted 19 hours agoComputational Protein Engineer
On-site
Requirements
- This role is primarily focused on computational modeling and simulation, using state-of-the-art AI and physics-based tools to engineer biological interfaces for critical material recovery.
- Responsibilities Computational Design & Generative AI: Deploy and refine advanced design suites (e.g., RFDiffusion 2/3, Rosetta, LigandMPNN) to architect novel binding pockets for polyvalent metal cations.
- Qualifications Education: Ph.D. in Computational Chemistry, Biophysics, Protein Engineering, or a related field. (Candidates with an M.S. and 5+ years of specialized
- experience in computational design/forcefield development will be considered).
- Technical Expertise: Deep proficiency in Molecular Dynamics (MD) simulations (GROMACS, AMBER, or NAMD) and the physics of metal-ligand coordination.
- Programming: Fluency in Python and/or C++/Rust for pipeline development and custom script generation. Citizenship: U.S.
- Experience with (or willingness to learn) biophysical characterization techniques (ITC, SPR, Fluorescence) to help interpret experimental data. Automation:
- Experience with high-throughput liquid handling robots or automated screening workflows.
- Bio-Interfacial Modeling: Knowledge of how proteins behave when tethered to solid surfaces (e.g., resin or silica).
- From AI-powered drones and loitering munitions to integrated autonomy and space resilience, our technologies shape the future of warfare and protect those who serve.
Benefits
- Clearance Level No Clearance The salary range for this role is: $88,500 - $125,475 AeroVironment considers several factors when extending an offer, including but not limited to, the location, the role and associated responsibilities, a candidate’s work experience, education/training, and key skills.
- benefits package including medical, dental vision, 401K with company matching, a 9/80 work schedule and a paid holiday shutdown.
- We are proud to be an EEO/AA Equal Opportunity Employer, including disability/veterans.
Contact
- For more information about our company benefit offerings please visit: http://www.avinc.com/myavbenefits .
- We also encourage you to review our company website at http://www.avinc.com to learn more about us. Principals only need apply. NO agencies please.
Additional details
- Worker Type Regular Job Description Position Overview The Biological Materials and Processing Research Team is seeking a Computational Protein Engineer to spearhead the de novo design and structural optimization of proteins for high-affinity ion coordination.
- Forcefield Development: Lead the development and validation of custom metal-ion forcefields for molecular dynamics (MD) simulations, ensuring accurate representation of coordination geometries.
- Quantum Chemistry: Utilize Density Functional Theory (DFT) and other QM methods to calculate electronic structures and refine transition-state models for bioinorganic complexes.
- Structural Bioinformatics: Characterize the thermodynamic landscape and conformational stability of engineered scaffolds using high-throughput structural analysis.
- Interdisciplinary Interface: Translate computational predictions into actionable design parameters for the "wet lab" team and collaborate on the integration of proteins into functional materials (hydrogels/membranes). Required
- Citizenship is required due to government facility access requirements.
- ITAR Requirement: This position requires access to information that is subject to compliance with the International Traffic Arms Regulations (“ITAR”) and/or the Export Administration Regulations (“EAR”).
- requirements of the ITAR and/or the EAR, applicants must qualify as a U.S. person under the ITAR and the EAR, or a person to be approved for an export license by the governing agency whose technology comes under its jurisdiction.
- Please understand that any job offer that requires approval of an export license will be conditional on AeroVironment’s determination that it will be able to obtain an export license in a time frame consistent with AeroVironment’s business requirements.
- A “U.S. person” according to the ITAR definition is a U.S. citizen, U.S. lawful permanent resident (green card holder), or protected individual such as a refugee or asylee.