research
Posted Apr 20Staff Scientist, New Product Development
at Natera
San Carlos, United StatesOn-site
Responsibilities
- Design, develop, and validate automated high-throughput NGS assays that will be run in a commercial CLIA laboratory
- Provide production support to automated high-throughput NGS assays currently run in commercial CLIA laboratories
- Manage assigned technical projects and associated timelines and deliverables in NGS-based assays. Mentor and manage the functional activities of junior employees
- Design and execute moderate to high complexity experiments and perform data analysis (e.g. JMP, R, Python, Excel)
- Coordinate with multiple internal groups (automation engineering, laboratory operations, bioinformatics, statistics, project and product management) and serve as point person/technical lead to ensure the successful and timely execution of projects
- Write study protocols, reports, and SOPs, train lab operations operators on protocols
- Identify areas for continuous improvement and actively contribute to the effort of introducing better practices to improve production workflows and shorten TAT for patient samples
- Demonstrated track record of development and validation of automated protocols for CLIA labs
Requirements
- experience in next generation sequencing (NGS) assay development who enjoys solving challenging and complex problems in a fast-paced environment.
- The ideal candidate is a driven professional who maintains broad knowledge of molecular biology and chemistry, and applies statistical principles to experiment design and analysis.
- The candidate should have an in-depth understanding of product development and support in a CLIA environment, and
- experience with current NGS oncology diagnostics devices. PRIMARY RESPONSIBILITIES:
- Ability to manage Scientists and Research Associates
- experience in assay development and automation for the life science industry.
- Well able to perform first-pass data analysis; strong ability to interpret experimental data
- Deep technical knowledge of NGS biology and processes
- Strong understanding of the chemistry underlying nucleic acid extraction, PCR, NGS library preparation, and hybrid capture technologies •
- Experience designing and executing studies including stability, guard banding, reproducibility and repeatability and QC method development