Manager, Genetic Product Quality (Fully Remote) — Variant Interpretation

Remote

Responsibilities

Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
Support high-impact client deliverables, including clinical and pharmaceutical use cases
Own QA/QC standards across all variant interpretation workflows
Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
Oversee external data quality, including ClinVar submissions and discrepancy resolution
Manage, mentor, and develop a team of QA scientists and curators
Design, implement, and continuously improve SOPs, QA processes, and workflows
Identify systemic quality issues and lead solutions that scale across teams and projects
Own Scientific Quality at Scale
Shape how variant interpretation is performed across products, clients, and public data resources. Lead and Build
Develop a high-performing team and establish systems that scale with the organization. Make a Real Impact

Genomenon is an AI-driven genetic intelligence company on a mission to save and improve lives by making biomedical information actionable.
We sit at the intersection of AI, genomics, and real world evidence.
Genomenon transforms the global scientific literature into a literature derived, real world evidence (RWE) engine for precision medicine—combining large-scale AI with expert human curation to deliver clean, clinically actionable datasets.
What makes Genomenon unique is our ability to support both clinical diagnostics and pharmaceutical innovation on a shared foundation of advanced AI, deep domain expertise, and rigorously curated data.
experience in a clinical or equivalent setting About the Opportunity:
Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications Leverage clinical
experience to contextualize variant interpretations and ensure clinical relevance and applicability
experience in a clinical or equivalent setting
Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
Proficiency in HGVS nomenclature, including normalization and variant disambiguation