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Posted 4 weeks agoManager, Genetic Product Quality (Fully Remote) — Variant Interpretation
at Genomenon
Remote
Responsibilities
- Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
- Support high-impact client deliverables, including clinical and pharmaceutical use cases
- Own QA/QC standards across all variant interpretation workflows
- Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
- Oversee external data quality, including ClinVar submissions and discrepancy resolution
- Manage, mentor, and develop a team of QA scientists and curators
- Design, implement, and continuously improve SOPs, QA processes, and workflows
- Identify systemic quality issues and lead solutions that scale across teams and projects
- Own Scientific Quality at Scale
- Shape how variant interpretation is performed across products, clients, and public data resources. Lead and Build
- Develop a high-performing team and establish systems that scale with the organization. Make a Real Impact
Requirements
- Genomenon is an AI-driven genetic intelligence company on a mission to save and improve lives by making biomedical information actionable.
- We sit at the intersection of AI, genomics, and real world evidence.
- Genomenon transforms the global scientific literature into a literature derived, real world evidence (RWE) engine for precision medicine—combining large-scale AI with expert human curation to deliver clean, clinically actionable datasets.
- What makes Genomenon unique is our ability to support both clinical diagnostics and pharmaceutical innovation on a shared foundation of advanced AI, deep domain expertise, and rigorously curated data.
- experience in a clinical or equivalent setting About the Opportunity:
- Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications Leverage clinical
- experience to contextualize variant interpretations and ensure clinical relevance and applicability
- experience in a clinical or equivalent setting
- Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
- Proficiency in HGVS nomenclature, including normalization and variant disambiguation